PHOX2B Antibody

Catalog Number:

25435

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q99453
Gene ID:8929

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 15 amino acid peptide near the center of human PHOX2B.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

PHOX2B antibody is predicted to not cross-react with other paired homeobox family members.

Applications:

ELISA WB

Background:

PHOX2A and PHOX2B (Paired mesoderm homeobox protein) are closely related, paired-homeodomain transcription factors that function as determinants of the noradrenergic phenotype during embryogenesis. PHOX2 proteins are crucial for the regulation of endogenous hydroxylases in neural crest cells and promote sympathetic neuron generation. Human PHOX2B contains one DNA binding homeobox domain and is required for the differentiation of all central and nonperipheral noradrenergic centers in the brain. In contrast, PHOX2A controls only the differentiation of the main noradrenergic center of the brain. Regulation of PHOX2 may have therapeutic utility in aging or disorders involving degeneration of noradrenergic neurons .

References:

appl_detail:

Datasheet PDF