Product Datasheet  
PHOX2B Antibody  
Catalog Number: 25435  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:Q99453
    Gene ID:8929
  • Form of Antibody：  
  • Supplied in PBS containing 0.02% sodium azide.
  • Storage：  
  • Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Immunogen：  
  • Raised against a 15 amino acid peptide near the center of human PHOX2B.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • other_names：  
  • Paired-like homeobox 2B, Paired mesoderm homeobox protein 2B, PMX2B, Neuroblastoma Phox, NBLST2, NBPhox
  • Purification：  
  • Affinity chromatography purified via peptide column
  • Specificity：  
  • PHOX2B antibody is predicted to not cross-react with other paired homeobox family members.
  • Applications：  
  • ELISA WB
  • Background：  
  • PHOX2A and PHOX2B (Paired mesoderm homeobox protein) are closely related, paired-homeodomain transcription factors that function as determinants of the noradrenergic phenotype during embryogenesis. PHOX2 proteins are crucial for the regulation of endogenous hydroxylases in neural crest cells and promote sympathetic neuron generation. Human PHOX2B contains one DNA binding homeobox domain and is required for the differentiation of all central and nonperipheral noradrenergic centers in the brain. In contrast, PHOX2A controls only the differentiation of the main noradrenergic center of the brain. Regulation of PHOX2 may have therapeutic utility in aging or disorders involving degeneration of noradrenergic neurons .



 
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