SIGLEC15 Antibody

Catalog Number:

25434

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q6ZMC9
Gene ID:284266

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 15 amino acid peptide near the amino terminus of human SIGLEC15.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

SIGLEC15 antibody is predicted to not cross-react with other SIGLEC family members.

Applications:

ELISA WB

Background:

Siglecs are vertebrate cell-surface lectins that recognize sialylated glycans and are involved in many physiological processes, such as glycoprotein turnover, cellular trafficking, and pathogen recognition. Most Siglecs are expressed on cells of the immune system. SIGLEC15 is a type-I transmembrane protein consisting of two immunoglobulin (Ig)-like domains, a transmembrane domain containing a lysine residue, and a short cytoplasmic tail. SIGLEC15 can interact with the activating adaptor molecules DAP12/10. Its activating signaling potential and unique preference for glycan recognition implies that SIGLEC15 may be involved in the immune surveillance of tumors and probably plays a conserved, regulatory role in the immune system of vertebrates.

References:

appl_detail:

Datasheet PDF