NKX2-2 Antibody

Catalog Number:

25430

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:O95096
Gene ID:4821

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 19 amino acid peptide near the center of human NKX2-2.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

NKX2-2 antibody is predicted to not cross-react with other NK2 homeobox family members.

Applications:

ELISA WB

Background:

NKX2-2 (NK2 homeobox 2) is a member of a family of transcription factors that are involved in embryonic development and cell fate. NKX2-2 is crucial in the development of pancreatic islet cell differentiation and activates the ghrelin-promoter in these cells. NKX2-2 is expressed at the onset of pancreatic epithelium formation and becomes restricted to mature α-, β- and PP cells , and in NKX2-2-null mice embryos, all β-cells and most a-cells are replaced by ghrelin-positive cells. NKX2-2 is also thought to be involved in ventral neuronal patterning and floor plate development and commissural axon guidance.

References:

appl_detail:

Datasheet PDF