GRB10 Antibody

Catalog Number:

25427

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q13322
Gene ID:2887

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 17 amino acid peptide near the carboxy terminus of human GRB10.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

At least three isoforms of GRB10 are known to exist; this antibody will detect all three isoforms.

Applications:

ELISA WB

Background:

GRB10 belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules and function in diverse cellular processes. GRB10 is a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of GRB10 inhibits tyrosine kinase activity and results in growth suppression. GRB10 can also interact with the L isoform of the proapoptotic protein Bim. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts .

References:

appl_detail:

Datasheet PDF