Product Datasheet  
GRB10 Antibody  
Catalog Number: 25427  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:Q13322
    Gene ID:2887
  • Form of Antibody：  
  • Supplied in PBS containing 0.02% sodium azide.
  • Storage：  
  • Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Immunogen：  
  • Raised against a 17 amino acid peptide near the carboxy terminus of human GRB10.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • other_names：  
  • Growth factor receptor-bound 10, RSS, IRBP, MEG1, GRB-IR
  • Purification：  
  • Affinity chromatography purified via peptide column
  • Specificity：  
  • At least three isoforms of GRB10 are known to exist; this antibody will detect all three isoforms.
  • Applications：  
  • ELISA WB
  • Background：  
  • GRB10 belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules and function in diverse cellular processes. GRB10 is a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of GRB10 inhibits tyrosine kinase activity and results in growth suppression. GRB10 can also interact with the L isoform of the proapoptotic protein Bim. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts .



 
© Signalway Biotechnology All Rights Reserved.