PIERCE1 Antibody

Catalog Number:

25426

Amount:

100μg

Price:

$319

Swiss-Prot No:

Q5BN46

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 16 amino acid peptide near the amino terminus of human PIERCE1.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

PIERCE1 antibody is predicted to not cross-react with other UPF0691 family members.

Applications:

ELISA WB

Background:

PIERCE1, also known as C9orf116, is an important p53 target gene contributing to normal DNA damage response and may play crucial roles in maintaining genomic integrity against genotoxic stresses, including UVC irradiation. PIERCE1 exists as two alternatively spliced isoforms and is predominantly expressed in human small cell lung cancer. PIERCE1 knockdown induces down-regulation of proapoptotic genes including Ei24, Apaf1 and PTEN, suggesting that PIERCE1 is a proapoptotic gene. It is helpful for in-depth understanding of p53 pathways and the design of new cancer therapies.

References:

appl_detail:

Datasheet PDF