Product Datasheet  
PIERCE1 Antibody  
Catalog Number: 25426  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Q5BN46
  • Form of Antibody：  
  • Supplied in PBS containing 0.02% sodium azide.
  • Storage：  
  • Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Immunogen：  
  • Raised against a 16 amino acid peptide near the amino terminus of human PIERCE1.
  • reactivity：  
  • Hu Ms
  • appl_detail：  
  • other_names：  
  • Pierce 1, C9orf116
  • Purification：  
  • Affinity chromatography purified via peptide column
  • Specificity：  
  • PIERCE1 antibody is predicted to not cross-react with other UPF0691 family members.
  • Applications：  
  • ELISA WB
  • Background：  
  • PIERCE1, also known as C9orf116, is an important p53 target gene contributing to normal DNA damage response and may play crucial roles in maintaining genomic integrity against genotoxic stresses, including UVC irradiation. PIERCE1 exists as two alternatively spliced isoforms and is predominantly expressed in human small cell lung cancer. PIERCE1 knockdown induces down-regulation of proapoptotic genes including Ei24, Apaf1 and PTEN, suggesting that PIERCE1 is a proapoptotic gene. It is helpful for in-depth understanding of p53 pathways and the design of new cancer therapies.



 
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