RKHD3 Antibody

Catalog Number:

25405

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q6ZN04
Gene ID:84206

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 16 amino acid peptide from near the center of human RKHD3.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

This antibody is specific for RKHD3 and will not recognize the other RKHD3 family of proteins.

Applications:

ELISA WB

Background:

Rkhd3, also known as MEX3B is a member of a novel family of four homologous human MEX3 proteins each containing two heterogeneous nuclear ribonucleoprotein K homology (KH) domains and one carboxy-terminal RING finger module. MEX3 proteins, including Rkhd3, are phosphoproteins that bind RNA through their KH domains and shuttle between the nucleus and the cytoplasm via the CRM1 export pathway. These proteins are a novel family of evolutionarily conserved RNA-binding proteins, differentially recruited to P bodies and potentially involved in post-transcriptional regulatory mechanisms. Rkhd3 is thought to act as a mechanism to fine-tune mRNA regulation in early Xenopus development, and with Rkhd4, but not Rkhd1, will co-localize with both the hDcp1a decapping factor and Argonaute (Ago) proteins in processing bodies (P bodies), recently characterized as centers of mRNA turnover.

References:

appl_detail:

Datasheet PDF