Product Datasheet  
RKHD3 Antibody  
Catalog Number: 25405  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:Q6ZN04
    Gene ID:84206
  • Form of Antibody：  
  • Supplied in PBS containing 0.02% sodium azide.
  • Storage：  
  • Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Immunogen：  
  • Raised against a 16 amino acid peptide from near the center of human RKHD3.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • other_names：  
  • RING finger and KH domain-containing protein 3, MEX3B, Ring finger protein 195, RNF195
  • Purification：  
  • Affinity chromatography purified via peptide column
  • Specificity：  
  • This antibody is specific for RKHD3 and will not recognize the other RKHD3 family of proteins.
  • Applications：  
  • ELISA WB
  • Background：  
  • Rkhd3, also known as MEX3B is a member of a novel family of four homologous human MEX3 proteins each containing two heterogeneous nuclear ribonucleoprotein K homology (KH) domains and one carboxy-terminal RING finger module. MEX3 proteins, including Rkhd3, are phosphoproteins that bind RNA through their KH domains and shuttle between the nucleus and the cytoplasm via the CRM1 export pathway. These proteins are a novel family of evolutionarily conserved RNA-binding proteins, differentially recruited to P bodies and potentially involved in post-transcriptional regulatory mechanisms. Rkhd3 is thought to act as a mechanism to fine-tune mRNA regulation in early Xenopus development, and with Rkhd4, but not Rkhd1, will co-localize with both the hDcp1a decapping factor and Argonaute (Ago) proteins in processing bodies (P bodies), recently characterized as centers of mRNA turnover.



 
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