CD33 Antibody

Catalog Number:

25387

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:P20138
Gene ID:945

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 14 amino acid peptide near the center of human CD33.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

At least three isoforms of CD33 are known to exist; this antibody will detect all three isoforms.

Applications:

ELISA WB

Background:

CD33 is a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family that is highly expressed on myeloid progenitor cells. Assessment of CD33 expression is of great importance in the immunodiagnosis of acute leukemia, allowing distinction between myeloid and lymphoid origin, as CD33 is generally restricted to the myelomonocytic lineage. CD33 can associate with the protein-tyrosine phosphatases SHP-1 and SHP-2 and thus could modulate downstream signaling events associated with cell activation. Common variants of CD33 have been found to be associated with late-onset Alzheimer’s disease.

References:

appl_detail:

Datasheet PDF