Product Datasheet  
CD33 Antibody  
Catalog Number: 25387  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:P20138
    Gene ID:945
  • Form of Antibody：  
  • Supplied in PBS containing 0.02% sodium azide.
  • Storage：  
  • Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Immunogen：  
  • Raised against a 14 amino acid peptide near the center of human CD33.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • other_names：  
  • Myeloid surface antigen CD33, p67, SIGLEC3
  • Purification：  
  • Affinity chromatography purified via peptide column
  • Specificity：  
  • At least three isoforms of CD33 are known to exist; this antibody will detect all three isoforms.
  • Applications：  
  • ELISA WB
  • Background：  
  • CD33 is a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family that is highly expressed on myeloid progenitor cells. Assessment of CD33 expression is of great importance in the immunodiagnosis of acute leukemia, allowing distinction between myeloid and lymphoid origin, as CD33 is generally restricted to the myelomonocytic lineage. CD33 can associate with the protein-tyrosine phosphatases SHP-1 and SHP-2 and thus could modulate downstream signaling events associated with cell activation. Common variants of CD33 have been found to be associated with late-onset Alzheimer’s disease.



 
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