ECRG4 Antibody

Catalog Number:

25369

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q9H1Z8
Gene ID:84417

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 20 amino acid peptide near the carboxy terminus of human ECRG4.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

ECRG4 antibody is predicted to not cross-react with other ECRG family members.

Applications:

ELISA WB

Background:

The esophageal cancer-related gene 4 (ECRG4), also known as Augurin, was identified through differential display screening between esophageal cancer and normal tissue. Hypermethylation of CpG sites in the ECRG4 promoter correlate with ECRG4 downregulation in numerous esophageal squamous cell carcinoma tissues.. In transfected cells, overexpression of ECRG4 induced G1 arrest, dephosphorylation of Rb and decreased expression of cyclins D1 and D3. Increased expression of ECRG4 in aged mouse brain is observed compared with young mouse brain. The increased ECRG4 level was accompanied by elevated senescence-associated acidic beta-galactosidase activity, suggesting that ECRG4 is involved in cellular differentiation and senescence.

References:

appl_detail:

Datasheet PDF