Product Datasheet  
ECRG4 Antibody  
Catalog Number: 25369  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:Q9H1Z8
    Gene ID:84417
  • Form of Antibody：  
  • Supplied in PBS containing 0.02% sodium azide.
  • Storage：  
  • Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Immunogen：  
  • Raised against a 20 amino acid peptide near the carboxy terminus of human ECRG4.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • other_names：  
  • Esophageal cancer-related gene 4 protein, Augurin, C2orf40
  • Purification：  
  • Affinity chromatography purified via peptide column
  • Specificity：  
  • ECRG4 antibody is predicted to not cross-react with other ECRG family members.
  • Applications：  
  • ELISA WB
  • Background：  
  • The esophageal cancer-related gene 4 (ECRG4), also known as Augurin, was identified through differential display screening between esophageal cancer and normal tissue. Hypermethylation of CpG sites in the ECRG4 promoter correlate with ECRG4 downregulation in numerous esophageal squamous cell carcinoma tissues.. In transfected cells, overexpression of ECRG4 induced G1 arrest, dephosphorylation of Rb and decreased expression of cyclins D1 and D3. Increased expression of ECRG4 in aged mouse brain is observed compared with young mouse brain. The increased ECRG4 level was accompanied by elevated senescence-associated acidic beta-galactosidase activity, suggesting that ECRG4 is involved in cellular differentiation and senescence.



 
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