SPRYD2 Antibody

Catalog Number:

25328

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q8N3K9
Gene ID:202333

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against an 18 amino acid peptide near the carboxy terminus of human SPRYD2.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

SPRYD2 antibody is predicted to not cross-react with other SPRYD protein family members. At least four isoforms of SPRYD2 are known to exist.

Applications:

ELISA WB

Background:

SPRYD2, also known as Myospryn, was originally identified as the muscle-specific partner of dysbindin and as a Mef-2 target gene. It is a large scaffolding protein localized to the Z-disc/costamere region of striated muscle. SPRYD2 includes a noncanonical tripartite motif (TRIM-like) that lacks the RING domain but consists of a B-box coiled coil (BBC), fibronectin 3 (FN3) repeats, and SPRY domains. SPRYD2 interacts with desmin and calcineurin, and it has been suggested to play a role in the biogenesis of lysosome and negatively regulates slow-fiber-type transformation and skeletal muscle regeneration. SPRYD2 is dysregulated in Duchenne muscular dystrophy.

References:

appl_detail:

Datasheet PDF