Product Datasheet  
SPRYD2 Antibody  
Catalog Number: 25328  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:Q8N3K9
    Gene ID:202333
  • Form of Antibody：  
  • Supplied in PBS containing 0.02% sodium azide.
  • Storage：  
  • Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Immunogen：  
  • Raised against an 18 amino acid peptide near the carboxy terminus of human SPRYD2.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • other_names：  
  • SPRY domain-containing protein 2, cardiomyopathy-associated protein 5, CMYA5, dystrobrevin-binding protein 2, DTNBP2, TRIM76
  • Purification：  
  • Affinity chromatography purified via peptide column
  • Specificity：  
  • SPRYD2 antibody is predicted to not cross-react with other SPRYD protein family members. At least four isoforms of SPRYD2 are known to exist.
  • Applications：  
  • ELISA WB
  • Background：  
  • SPRYD2, also known as Myospryn, was originally identified as the muscle-specific partner of dysbindin and as a Mef-2 target gene. It is a large scaffolding protein localized to the Z-disc/costamere region of striated muscle. SPRYD2 includes a noncanonical tripartite motif (TRIM-like) that lacks the RING domain but consists of a B-box coiled coil (BBC), fibronectin 3 (FN3) repeats, and SPRY domains. SPRYD2 interacts with desmin and calcineurin, and it has been suggested to play a role in the biogenesis of lysosome and negatively regulates slow-fiber-type transformation and skeletal muscle regeneration. SPRYD2 is dysregulated in Duchenne muscular dystrophy.



 
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