TMEM88 Antibody

Catalog Number:

25326

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q6PEY1
Gene ID:92162

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 19 amino acid peptide near the carboxy terminus of human TMEM88.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

At least two isoforms of TMEM88 are known to exist; this antibody will recognize both isoforms.

Applications:

ELISA WB

Background:

Transmembrane protein 88 (TMEM88) is a two-transmembrane-type protein whose C-terminal tail has been shown to bind the PDZ domain of Dishevelled (Dvl), one of the key components in Wnt signaling pathways. TMEM88 attentuated the Wnt/beta-catenin signaling induced by Wnt-1 ligand in a dose-dependent manner and knockdown of TMEM88 by RNAi increased Wnt activity, suggesting that TMEM88 plays a role in regulating Wnt signaling in a context-dependent manner.

References:

appl_detail:

Datasheet PDF