SIK2 Antibody

Catalog Number:

25302

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q9H0K1
Gene ID:23235

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 16 amino acid peptide near the center of human SIK2.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

SIK2 antibody is predicted to not cross-react with other SIK protein family members.

Applications:

ELISA WB

Background:

Salt-inducible kinase 2 (SIK2), like its closely related homolog SIK1, belongs AMPK subfamily of the Ser/Thr protein kinase family and negatively regulates CRE-binding protein (CREB) activity by phosphorylating the CREB-specific coactivator transducer of regulated CREB activity (TORC). SIK2 is thought to be part of a signaling cascade that regulates the expression and activity of the insulin-induced genes PGC-1?alpha and UCP-1 in brown adipocytes, impairment of which has been implicated in obesity and insulin resistance in human and animal models. SIK2 has also been reported as a key regulator for neuronal survival after ischemia, suppressing CREB-mediated gene expression after oxygen-glucose deprivation.

References:

appl_detail:

Datasheet PDF