Product Datasheet  
SIK2 Antibody  
Catalog Number: 25302  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:Q9H0K1
    Gene ID:23235
  • Form of Antibody：  
  • Supplied in PBS containing 0.02% sodium azide.
  • Storage：  
  • Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Immunogen：  
  • Raised against a 16 amino acid peptide near the center of human SIK2.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • other_names：  
  • Salt-inducible protein kinase 2, Serine, threonine-protein kinase SNF1-like kinase 2, SNF1LK2, QIK, LOH11CR1I
  • Purification：  
  • Affinity chromatography purified via peptide column
  • Specificity：  
  • SIK2 antibody is predicted to not cross-react with other SIK protein family members.
  • Applications：  
  • ELISA WB
  • Background：  
  • Salt-inducible kinase 2 (SIK2), like its closely related homolog SIK1, belongs AMPK subfamily of the Ser/Thr protein kinase family and negatively regulates CRE-binding protein (CREB) activity by phosphorylating the CREB-specific coactivator transducer of regulated CREB activity (TORC). SIK2 is thought to be part of a signaling cascade that regulates the expression and activity of the insulin-induced genes PGC-1?alpha and UCP-1 in brown adipocytes, impairment of which has been implicated in obesity and insulin resistance in human and animal models. SIK2 has also been reported as a key regulator for neuronal survival after ischemia, suppressing CREB-mediated gene expression after oxygen-glucose deprivation.



 
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