PION Antibody

Catalog Number:

25252

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:A4D1B5
Gene ID:54103

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 19 amino acid peptide near the carboxy terminus of human PION.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

Multiple isoforms of PION are known to exist. PION antibody is predicted to not cross-react with other F-box protein family members.

Applications:

ELISA WB IHC

Background:

Accumulation of the amyloid-beta peptide (Abeta) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. The beta?amyloid protein precursor (APP) is cleaved by one of two beta?secretases (BACE and BACE2), producing a soluble derivative of the protein and a membrane anchored 99 -amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma?secretase to generate the 4 kDa amyloid-beta peptide (Abeta), which is deposited in the Alzheimer’s disease patients�?brains. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and the APP C-terminal fragment, suggesting that PION may be a potential therapeutic target for the treatment of Alzheimer’s disease.

References:

appl_detail:

Datasheet PDF