Product Datasheet  
PION Antibody  
Catalog Number: 25252  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:A4D1B5
    Gene ID:54103
  • Form of Antibody：  
  • Supplied in PBS containing 0.02% sodium azide.
  • Storage：  
  • Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Immunogen：  
  • Raised against a 19 amino acid peptide near the carboxy terminus of human PION.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • other_names：  
  • Protein pigeon homolog, gamma-secretase activating protein, GSAP
  • Purification：  
  • Affinity chromatography purified via peptide column
  • Specificity：  
  • Multiple isoforms of PION are known to exist. PION antibody is predicted to not cross-react with other F-box protein family members.
  • Applications：  
  • ELISA WB IHC
  • Background：  
  • Accumulation of the amyloid-beta peptide (Abeta) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. The beta?amyloid protein precursor (APP) is cleaved by one of two beta?secretases (BACE and BACE2), producing a soluble derivative of the protein and a membrane anchored 99 -amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma?secretase to generate the 4 kDa amyloid-beta peptide (Abeta), which is deposited in the Alzheimer’s disease patients�?brains. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and the APP C-terminal fragment, suggesting that PION may be a potential therapeutic target for the treatment of Alzheimer’s disease.



 
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