NUMB Antibody

Catalog Number:

25307

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:P49757
Gene ID:8650

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 17 amino acid peptide near the carboxy terminus of human NUMB.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

At least four isoforms of NUMB are known to exist; this antibody will detect all of them.

Applications:

ELISA WB

Background:

NUMB, the mammalian homolog to the Drosophila asymmetric cell fate determinant NUMB, is thought to share several features molecular mechanisms in mammalian cells, generating asymmetric cell divisions during neurogenesis in vertebrate development as well as in hematopoietic stem cells. NUMB has been shown to inhibit Notch signaling, and is itself regulated by ubiquitinylation by MDM2. NUMB has also been shown to help activate the tumor suppressor p53, suggesting that loss of NUMB in cancerous cells would not only activate the potential oncogene Notch, but diminish the tumor suppressing effect of p53.

References:

appl_detail:

Datasheet PDF