Product Datasheet  
NUMB Antibody  
Catalog Number: 25307  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:P49757
    Gene ID:8650
  • Form of Antibody：  
  • Supplied in PBS containing 0.02% sodium azide.
  • Storage：  
  • Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Immunogen：  
  • Raised against a 17 amino acid peptide near the carboxy terminus of human NUMB.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • other_names：  
  • m-NUMB, S171
  • Purification：  
  • Affinity chromatography purified via peptide column
  • Specificity：  
  • At least four isoforms of NUMB are known to exist; this antibody will detect all of them.
  • Applications：  
  • ELISA WB
  • Background：  
  • NUMB, the mammalian homolog to the Drosophila asymmetric cell fate determinant NUMB, is thought to share several features molecular mechanisms in mammalian cells, generating asymmetric cell divisions during neurogenesis in vertebrate development as well as in hematopoietic stem cells. NUMB has been shown to inhibit Notch signaling, and is itself regulated by ubiquitinylation by MDM2. NUMB has also been shown to help activate the tumor suppressor p53, suggesting that loss of NUMB in cancerous cells would not only activate the potential oncogene Notch, but diminish the tumor suppressing effect of p53.



 
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