JMJD1A Antibody

Catalog Number:

24955

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q9Y4C1
Gene ID:55818

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 16 amino acid peptide from near the amino terminus of human JMJD1A.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

This antibody will not cross-react with JMJD1B or JMJD1C.

Applications:

ELISA WB IHC

Background:

The jumonji domain containing 1A protein (JMJD1A) was originally discovered as a testes specific gene, but has been found to be expressed in numerous tissues. JMJD1A is a histone demethylase and specifically demethylates mono- and dimethyl-H3K9. It has also been found to be a novel interaction partner with ER71, a transcription factor expressed in the testes of adult mice and during embryogenesis. JMJD1A is also a downstream gene of STAT3, a protein that has been found to be important in the maintenance of mouse embryonic stem (mES) cells, and decreased JMJD1A expression correlated with the differentiation of cultured mES cells following the removal of the cytokine LIF. These findings suggest that JMJD1A might be a critical signaling molecule underlying the maintenance of pluripotency in embryonic stem cells. At least two isoforms of JMJD1A are known to exist.

References:

appl_detail:

Datasheet PDF