Product Datasheet  
JMJD1A Antibody  
Catalog Number: 24955  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:Q9Y4C1
    Gene ID:55818
  • Form of Antibody：  
  • Supplied in PBS containing 0.02% sodium azide.
  • Storage：  
  • Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Immunogen：  
  • Raised against a 16 amino acid peptide from near the amino terminus of human JMJD1A.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • other_names：  
  • Lysine-specific demethylase 3A, KDM3A, JHDM2A, JHMD2A, TSGA
  • Purification：  
  • Affinity chromatography purified via peptide column
  • Specificity：  
  • This antibody will not cross-react with JMJD1B or JMJD1C.
  • Applications：  
  • ELISA WB IHC
  • Background：  
  • The jumonji domain containing 1A protein (JMJD1A) was originally discovered as a testes specific gene, but has been found to be expressed in numerous tissues. JMJD1A is a histone demethylase and specifically demethylates mono- and dimethyl-H3K9. It has also been found to be a novel interaction partner with ER71, a transcription factor expressed in the testes of adult mice and during embryogenesis. JMJD1A is also a downstream gene of STAT3, a protein that has been found to be important in the maintenance of mouse embryonic stem (mES) cells, and decreased JMJD1A expression correlated with the differentiation of cultured mES cells following the removal of the cytokine LIF. These findings suggest that JMJD1A might be a critical signaling molecule underlying the maintenance of pluripotency in embryonic stem cells. At least two isoforms of JMJD1A are known to exist.



 
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