THEM4 Antibody

Catalog Number:

24916

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q5T1C6
Gene ID:117145

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against an 18 amino acid peptide near the center of human THEM4.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

The additional higher molecular weight bands seen in the immunoblot may represent post-translationally modified TMEM4.

Applications:

ELISA WB IHC

Background:

THEM4, also known as CTMP, binds specifically to the carboxy-terminal regulatory domain of PKB/Akt at the plasma membrane and acts as a negative regulator, reversing the phenotype of v-Akt-transformed cells. Hypermethylation of the THEM4 promoter and transcriptional downregulation of the gene has been reported in multiple glioblastomas, suggesting that epigenetic regulation of THEM4 may play a role in the progression of this cancer. Bioinformatic analysis, confirmed by in vitro testing, indicates that THEM4 is a broad-range, high activity acyl-CoA thioesterase. Recent reports have also indicated that TMEM4 is a mitochondrial protein whose overexpression is associated with an increase in mitochondrial membrane depolarization and caspase-3 and PARP cleavage, suggesting that THEM4 is involved in the apoptotic program.

References:

appl_detail:

Datasheet PDF