Product Datasheet  
THEM4 Antibody  
Catalog Number: 24916  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:Q5T1C6
    Gene ID:117145
  • Form of Antibody：  
  • Supplied in PBS containing 0.02% sodium azide.
  • Storage：  
  • Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Immunogen：  
  • Raised against an 18 amino acid peptide near the center of human THEM4.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • other_names：  
  • Thioesterase superfamily member 4, Carboxy-terminal modulator protein, CTMP
  • Purification：  
  • Affinity chromatography purified via peptide column
  • Specificity：  
  • The additional higher molecular weight bands seen in the immunoblot may represent post-translationally modified TMEM4.
  • Applications：  
  • ELISA WB IHC
  • Background：  
  • THEM4, also known as CTMP, binds specifically to the carboxy-terminal regulatory domain of PKB/Akt at the plasma membrane and acts as a negative regulator, reversing the phenotype of v-Akt-transformed cells. Hypermethylation of the THEM4 promoter and transcriptional downregulation of the gene has been reported in multiple glioblastomas, suggesting that epigenetic regulation of THEM4 may play a role in the progression of this cancer. Bioinformatic analysis, confirmed by in vitro testing, indicates that THEM4 is a broad-range, high activity acyl-CoA thioesterase. Recent reports have also indicated that TMEM4 is a mitochondrial protein whose overexpression is associated with an increase in mitochondrial membrane depolarization and caspase-3 and PARP cleavage, suggesting that THEM4 is involved in the apoptotic program.



 
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