ZBED1 Antibody

Catalog Number:

24868

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:O96006
Gene ID:9189

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 15 amino acid peptide from near the center of human ZBED1.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

This antibody is predicted to have no cross-reactivity to ZBED2 or ZBED3.

Applications:

ELISA WB

Background:

ZBED1, also known as DREF, is the human homolog of the Drosophila protein DREF, a transcriptional regulatory factor required for expression of genes involved in DNA replication and cell proliferation. RNA interference (RNAi) experiments targeting ZBED1 RNA resulted in the inhibition of S phase entry and reduction of histone H1 mRNA in HeLa cells, suggesting that ZBED1 also plays a role in cell proliferation in human cells. At least 22 ribosomal proteins (RPs) possess ZBED1 binding sites in their promoters; anti-ZBED1 RNAi also resulted in decreased RP gene expression. Immunoprecipitation analyses have shown that ZBED1 self-associates in vivo via a carboxyl-terminal hATC domain, and this self-association is required for nuclear localization and DNA binding.

References:

appl_detail:

Datasheet PDF