Product Datasheet  
ZBED1 Antibody  
Catalog Number: 24868  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:O96006
    Gene ID:9189
  • Form of Antibody：  
  • Supplied in PBS containing 0.02% sodium azide.
  • Storage：  
  • Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Immunogen：  
  • Raised against a 15 amino acid peptide from near the center of human ZBED1.
  • reactivity：  
  • Hu Ms
  • appl_detail：  
  • other_names：  
  • ZBED1, Zinc finger BED-type domain containing 1, ALTE, TRAMP, DREF, hDREF
  • Purification：  
  • Affinity chromatography purified via peptide column
  • Specificity：  
  • This antibody is predicted to have no cross-reactivity to ZBED2 or ZBED3.
  • Applications：  
  • ELISA WB
  • Background：  
  • ZBED1, also known as DREF, is the human homolog of the Drosophila protein DREF, a transcriptional regulatory factor required for expression of genes involved in DNA replication and cell proliferation. RNA interference (RNAi) experiments targeting ZBED1 RNA resulted in the inhibition of S phase entry and reduction of histone H1 mRNA in HeLa cells, suggesting that ZBED1 also plays a role in cell proliferation in human cells. At least 22 ribosomal proteins (RPs) possess ZBED1 binding sites in their promoters; anti-ZBED1 RNAi also resulted in decreased RP gene expression. Immunoprecipitation analyses have shown that ZBED1 self-associates in vivo via a carboxyl-terminal hATC domain, and this self-association is required for nuclear localization and DNA binding.



 
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