STEAP3 Antibody

Catalog Number:

24568

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q658P3
Gene ID:55240

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 15 amino acid peptide from near the amino terminus of human STEAP3.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

This STEAP3 antibody does not cross-react with other STEAP proteins.

Applications:

ELISA WB IHC

Background:

The six-transmembrane epithelial antigen of prostate 3 (STEAP3) is a member of a family of metalloreductases identified as cell-surface antigens in prostate tissue. Similar to two other members of the STEAP family (STEAP 2 and STEAP4), STEAP3 promotes both iron and copper reduction. STEAP3 is highly expressed in hematopoietic tissues and colocalizes with the transferrin endosome. Overexpression of STEAP3 stimulates iron reduction; mice lacking STEAP3 are deficient in erythroid ferrireductase activity, suggesting that STEAP3 is an endosomal ferrireductase required for transferrin-dependent iron uptake in erythroid cells.

References:

appl_detail:

Datasheet PDF