GAP43 Antibody

Catalog Number:	48583
other_names:	Axonal membrane protein GAP 43 antibody Axonal membrane protein GAP-43 antibody B 50 antibody Calmodulin binding protein P 57 antibody F1 antibody GAP 43 antibody GAP43 antibody Growth Associated Protein 43
Amount:	100μg
calculated_mw:	43 kDa
host_species:	Rabbit
Price:	$319
Swiss-Prot No:	Swiss-Prot#:P06837
Form of Antibody:	1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Storage/Stability:
Immunogen:	peptide
Purification:	Peptide affinity purified
Specificity/Sensitivity:
Applications:	WB, ICC, IHC, FC
Background:	GAP43, is a nervous tissue-specific cytoplasmic protein that can be attached to the membrane via a dual palmitoylation sequence on cysteines 3 and 4. This sequence targets GAP43 to lipid rafts. It is a major protein kinase C (PKC) substrate and is considered to play a key role in neurite formation, regeneration, and plasticity. The role of GAP-43 in CNS development is not limited to effects on axons: It is also a component of the centrosome, and differentiating neurons that do not express GAP-43 show mislocalization of the centrosome and mitotic spindles, particularly in neurogenic cell divisions. As a consequence, in the cerebellum, the neuronal precursor pool fails to expand normally and the cerebellum is significantly smaller.
References:
appl_detail:	WB: 1:1,000 IHC: 1:200 ICC: 1:200 FC: 1:100-1:200
	Datasheet PDF

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