Product Datasheet  
GAP43 Antibody  
Catalog Number: 48583  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:P06837
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • peptide
  • reactivity：  
  • Hu, Ms, Rt
  • appl_detail：  
  • WB: 1:1,000
    IHC: 1:200
    ICC: 1:200

    FC: 1:100-1:200
  • other_names：  
  • Axonal membrane protein GAP 43 antibody
    Axonal membrane protein GAP-43 antibody
    B 50 antibody
    Calmodulin binding protein P 57 antibody
    F1 antibody
    GAP 43 antibody
    GAP43 antibody
    Growth Associated Protein 43
  • Purification：  
  • Peptide affinity purified
  • Specificity：  
  • Applications：  
  • WB, ICC, IHC, FC
  • Background：  
  • GAP43, is a nervous tissue-specific cytoplasmic protein that can be attached to the membrane via a dual palmitoylation sequence on cysteines 3 and 4. This sequence targets GAP43 to lipid rafts. It is a major protein kinase C (PKC) substrate and is considered to play a key role in neurite formation, regeneration, and plasticity. The role of GAP-43 in CNS development is not limited to effects on axons: It is also a component of the centrosome, and differentiating neurons that do not express GAP-43 show mislocalization of the centrosome and mitotic spindles, particularly in neurogenic cell divisions. As a consequence, in the cerebellum, the neuronal precursor pool fails to expand normally and the cerebellum is significantly smaller.



 
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