FBXL18 Antibody

Catalog Number:

48543

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q96ME1

Form of Antibody:

1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to human FBXL18 aa 750 to C terminus.

Purification:

Peptide affinity purified.

Specificity/Sensitivity:

Applications:

WB,IHC,FC

Background:

FBL18 (F-box and leucine-rich repeat protein 18), also known as FBXL18, is an 805 amino acid protein that contains an F-box near its N-terminus, followed by several leucine-rich repeats and a transmembrane domain at the C-terminus. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune response, signaling cascades and developmental processes) through the targeting of proteins, such as cyclins and cyclin-dependent kinase inhibitors (CDKNs), for degradation by the proteasome after ubiquitination. FBL18 directly interacts with SKP1A p19 and CUL-1, forming a substrate-recognition component of the SCF-type E3 ubiquitin ligase complex. Four isoforms of FBL18 exist due to alternative splicing.

References:

appl_detail:

WB: 1:500
IHC: 1:50-1:200


FC: 1:50-1:100

Datasheet PDF