Product Datasheet  
FBXL18 Antibody  
Catalog Number: 48543  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q96ME1
  • Form of Antibody：  
  • 1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthetic peptide corresponding to human FBXL18 aa 750 to C terminus.
  • reactivity：  
  • Hu, Ms, Rt
  • appl_detail：  
  • WB: 1:500
    IHC: 1:50-1:200


    FC: 1:50-1:100
  • other_names：  
  • F box and leucine rich repeat protein 18 antibody
    F box/LRR repeat protein 18 antibody
    FBL18 antibody
    FBXL 18 antibody
    FLJ10776 antibody
    FLJ11467 antibody
    FLJ26934 antibody
    FLJ38075 antibody
    F
  • Purification：  
  • Peptide affinity purified.
  • Specificity：  
  • Applications：  
  • WB,IHC,FC
  • Background：  
  • FBL18 (F-box and leucine-rich repeat protein 18), also known as FBXL18, is an 805 amino acid protein that contains an F-box near its N-terminus, followed by several leucine-rich repeats and a transmembrane domain at the C-terminus. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune response, signaling cascades and developmental processes) through the targeting of proteins, such as cyclins and cyclin-dependent kinase inhibitors (CDKNs), for degradation by the proteasome after ubiquitination. FBL18 directly interacts with SKP1A p19 and CUL-1, forming a substrate-recognition component of the SCF-type E3 ubiquitin ligase complex. Four isoforms of FBL18 exist due to alternative splicing.



 
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