Bcl-2 Antibody

Catalog Number:

48496

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:P10415

Form of Antibody:

1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Storage/Stability:

Immunogen:

Synthetic peptide (KLH-coupled) within human Bcl-2 aa 20-80.

Purification:

Peptide affinity purified

Specificity/Sensitivity:

Applications:

WB, ICC, IHC, FC

Background:

Damage to the Bcl-2 gene has been identified as a cause of a number of cancers, including melanoma, breast, prostate, chronic lymphocytic leukemia, and lung cancer, and a possible cause of schizophrenia and autoimmunity. It is also a cause of resistance to cancer treatments. Antibodies to Bcl-2 can be used with immunohistochemistry to identify cells containing the antigen. In healthy tissue, these antibodies will react with B-cells in the mantle zone, as well as some T-cells. However, there is a considerable increase in positive cells in follicular lymphoma, as well as many other forms of cancer. In some cases, the presence or absence of Bcl-2 staining in biopsies may be significant for the patient's prognosis or likelihood of relapse.

References:

appl_detail:

WB: 1:500
IHC: 1:200
ICC: 1:200

FC: 1:50-1:100

Datasheet PDF