ICAM-1 Antibody

Catalog Number:

48266

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:P05362

Form of Antibody:

1*TBS (pH7.4),1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Storage/Stability:

Immunogen:

peptide

Purification:

Protein A purified

Specificity/Sensitivity:

Applications:

WB, IHC

Background:

Antigen-specific cell contacts in the immune system are strengthened by antigen-nonspecific interactions, mediated in part by lymphocyte-function associated (LFA) antigens. Recently, ICAM-1 (intercellular adhesion molecule-1) has been defined as a ligand for LFA-1. Monoclonal antibodies to ICAM-1 block T lymphocyte adhesion to fibroblasts and endothelial cells and disrupt the interaction between cytotoxic T cells and target cells. ICAM-1 is found on leukocytes, fibroblasts, epithelial cells and endothelial cells and its expression is regulated by inflammatory cytokines. The normal function of human ICAM-1 is to provide adhesion between endothelial cells and leukocytes after injury or stress. However, ICAM-1 is also used as a receptor by the major group of human rhinoviruses and is a catalyst for the subsequent viral uncoating during cell entry. Monoclonal antibodies recognize a 95 kDa cell surface glycoprotein the major human rhinovirus receptor, ICAM-1

References:

appl_detail:

WB: 1:1,000
IHC: 1:100

Datasheet PDF