IkappaB alpha Antibody

Catalog Number:

48264

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:P25963

Form of Antibody:

1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Storage/Stability:

Immunogen:

peptide

Purification:

Protein A purified

Specificity/Sensitivity:

Applications:

WB, IHC, ICC, IP

Background:

The NF-κB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IκB-α protein. In response to many different NF-κB-inducing agentsincluding T-cell mitogens, proinflammatory cytokines, and viral transactivatorsthe inhibitory IκB-α is rapidly phosphorylated and degraded. Phosphorylation of IκB-α at Ser32 and Ser36 has been shown to stimulate conjugation with ubiquitin and subsequent degradation of IκB-α. Phosphorylation of IκB-α at Ser32 and Ser36 is critical for activation of NF-κB, which then translocates to the nucleus and induces transcription of genes that protect organism.

References:

appl_detail:

WB: 1:1,000
IHC: 1:100
ICC: 1:100
IP: 1:10-100

Datasheet PDF