Product Datasheet  
IkappaB alpha Antibody  
Catalog Number: 48264  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:P25963
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • peptide
  • reactivity：  
  • Hu, Ms, Rt
  • appl_detail：  
  • WB: 1:1,000
    IHC: 1:100
    ICC: 1:100
    IP: 1:10-100
  • other_names：  
  • I kappa B alpha antibody
    I-kappa-B-alpha antibody
    IkappaBalpha antibody
    IkB-alpha antibody
    IKBA antibody
    IKBA_HUMAN antibody
    IKBalpha antibody
    MAD 3 antibody
    MAD3 antibody
    Major histocompatibi
  • Purification：  
  • Protein A purified
  • Specificity：  
  • Applications：  
  • WB, IHC, ICC, IP
  • Background：  
  • The NF-κB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IκB-α protein. In response to many different NF-κB-inducing agentsincluding T-cell mitogens, proinflammatory cytokines, and viral transactivatorsthe inhibitory IκB-α is rapidly phosphorylated and degraded. Phosphorylation of IκB-α at Ser32 and Ser36 has been shown to stimulate conjugation with ubiquitin and subsequent degradation of IκB-α. Phosphorylation of IκB-α at Ser32 and Ser36 is critical for activation of NF-κB, which then translocates to the nucleus and induces transcription of genes that protect organism.



 
© Signalway Biotechnology All Rights Reserved.