Estrogen Receptor alpha Antibody

Catalog Number:

48263

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:P03372

Form of Antibody:

1*TBS (pH7.4), 0.5%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Storage/Stability:

Immunogen:

peptide

Purification:

Tissue culture supernatant

Specificity/Sensitivity:

Applications:

WB, IHC

Background:

Estrogen receptor alpha (ER alpha) is a nuclear protein and member of the steroid hormone receptor family. ER alpha possesses both DNA binding and ligand binding domains, and exerts a significant role in activating the transcription of certain genes (1). Ligand-dependent dimerization and phosphorylation both function to regulate the transcriptional activation of ER alpha (2). The ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to anti-estrogen (e.g. tamoxifen) therapy (3).

References:

appl_detail:

WB: 1:500-1:1000
IHC: 1:500-1000

Datasheet PDF