Bcl-x Antibody

Catalog Number:

48262

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q07817

Form of Antibody:

1*TBS (pH7.4), 0.5%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Storage/Stability:

Immunogen:

peptide

Purification:

Protein A purified

Specificity/Sensitivity:

Applications:

WB, ICC, IHC, FC, IP

Background:

Bcl-x, a member of the Bcl-2 protein family, inhibits cell death, or apoptosis (1). Bcl-x is expressed as two isomeric forms, Bcl-xL and Bcl-xS, and is typically present in the cytosol in association with the mitochondrial membrane. Bcl-xL forms heterodimers with various proteins, including Bax, Bak and Bcl-2 (2). It has been found that heterodimerization with Bax does not seem to be required for anti-apoptotic activity (3). Since Bcl-xL can form an ion channel in synthetic lipid membranes, there is a strong possibility that this property plays a role in heterodimerization-independent cell survival (4). The Bcl-X(S) isoform promotes apoptosis.

References:

appl_detail:

WB: 1:500-1,000
IHC: 1:50-100
ICC: 1:100
IP: 1:10
FC: 1:50

Datasheet PDF