eIF-4E Antibody

Catalog Number:

48249

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:P06730

Form of Antibody:

1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.

Storage/Stability:

Immunogen:

Peptide

Purification:

Peptide affinity purified

Specificity/Sensitivity:

Applications:

WB, ICC, IHC, FC

Background:

The initiation of protein synthesis in eukaryotic cells is regulated by interactions between protein initiation factors and RNA molecules. The eukaryotic initiation complex eIF4F exists in vitro as a trimeric complex of eIF4E, eIF4A and eIF4G. Together, the complex allows ribosome binding to mRNA by inducing the unwinding of mRNA secondary structures. eIF4E binds to the mRNA "cap" during an early step in the initiation of protein synthesis. eIF4A acts as an ATP-dependent RNA helicase. eIF4G acts as a bridge between eIF4E, eIF4A and the eIF3 complex.

References:

appl_detail:

WB: 1:500-1:1,000 FC: 1:50-1:100

IHC: 1:50-1:100
ICC: 1:50-1:200

FC: 1:50-1:100

Datasheet PDF