PDGF Receptor beta Antibody

Catalog Number:

48234

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:P09619

Form of Antibody:

1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.

Storage/Stability:

Immunogen:

Peptide

Purification:

Peptide affinity purified

Specificity/Sensitivity:

Applications:

WB,ICC,IHC,FC

Background:

Platelet-derived growth factor (PDGF) is a mitogen for mesenchyme- and glia-derived cells. PDGF consists of two chains, A and B, which dimerize to form functionally distinct isoforms, PGDF-AA, PDGF-AB and PDGF-BB. These three isoforms bind with different affinities to two receptor types, PDGFR-α and -β, which are endowed with protein tyrosine kinase domains. PDGFR-α can bind to both A and B subunits of PDGF, while PDGFR- PDGF-AA induces the dimerization of αα and αβ and PDGF-BB induces the formation of three types of PDGF-AB induces dimerization of αα and αβ and PDGF-BB induces the formation of three types A dimlist, αα, αβ and ββ. Translocation of the PDGFR-β gene with the Tel gene is linked to chronic myelomonocytic leukemia (CMML), a myelodysplastic syndrome, and demonstrate the oncogenic potential of the PDGF receptors.

References:

appl_detail:

IHC: 1:50-1:200
ICC: 1:50-1:200

Datasheet PDF