Product Datasheet  
PDGF Receptor beta Antibody  
Catalog Number: 48234  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:P09619
  • Form of Antibody：  
  • 1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Peptide
  • reactivity：  
  • Hu, Ms, Rt
  • appl_detail：  

  • IHC: 1:50-1:200
    ICC: 1:50-1:200

  • other_names：  
  • Beta platelet derived growth factor receptor antibody
    Beta-type platelet-derived growth factor receptor antibody
    CD 140B antibody
    CD140 antigen-like family member B antibody
    CD140b antibody
    CD140b antigen antibody
  • Purification：  
  • Peptide affinity purified
  • Specificity：  
  • Applications：  
  • WB,ICC,IHC,FC
  • Background：  
  • Platelet-derived growth factor (PDGF) is a mitogen for mesenchyme- and glia-derived cells. PDGF consists of two chains, A and B, which dimerize to form functionally distinct isoforms, PGDF-AA, PDGF-AB and PDGF-BB. These three isoforms bind with different affinities to two receptor types, PDGFR-α and -β, which are endowed with protein tyrosine kinase domains. PDGFR-α can bind to both A and B subunits of PDGF, while PDGFR- PDGF-AA induces the dimerization of αα and αβ and PDGF-BB induces the formation of three types of PDGF-AB induces dimerization of αα and αβ and PDGF-BB induces the formation of three types A dimlist, αα, αβ and ββ. Translocation of the PDGFR-β gene with the Tel gene is linked to chronic myelomonocytic leukemia (CMML), a myelodysplastic syndrome, and demonstrate the oncogenic potential of the PDGF receptors.



 
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