Beclin 1 Antibody

Catalog Number:

48222

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q14457

Form of Antibody:

1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Storage/Stability:

Immunogen:

Synthetic peptide (KLH-coupled) within human Beclin 1 aa 380-450.

Purification:

Peptide affinity purified

Specificity/Sensitivity:

Applications:

ICC, IHC

Background:

Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis. Protects against infection by a neurovirulent strain of Sindbis virus. May play a role in antiviral host defense.

References:

appl_detail:

IHC: 1:200
ICC: 1:50-1:100

Datasheet PDF