VGLL1 Antibody

Catalog Number:

47455

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q99990
NCBI Gene ID:51442
Gene Accssion:NP_057351

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human VGLL1

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total VGLL1 protein.

Applications:

WB

Background:

The protein encoded by this gene binds proteins of the TEA domain family of transcription factors (TEFs) through the Vg (vestigial) homology region found in its N-terminus. It may thus function as a specific coactivator for the mammalian TEFs. TDU interacted directly with the TEA domain family member, TEF1, and deletion of the Vg homology region abolished the interaction. The TDU-TEF1 dimer activated a reporter plasmid, and expression of TDU in Drosophila rescued loss of Vg function. The interaction was stronger in cardiac myocytes, suggesting a myocyte-specific factor may participate in the interaction. Vgll1 was weakly active in driving expression of a reporter gene from the mouse skeletal muscle alpha-actin promoter, and Vgll1 could partially reverse the inhibitory effect of TEF1 in this assay.

References:

appl_detail:

WB dilution:1:2000-10000

Datasheet PDF