Product Datasheet  
VGLL1 Antibody  
Catalog Number: 47455  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q99990
    NCBI Gene ID:51442
    Gene Accssion:NP_057351
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthetic peptide of human VGLL1
  • reactivity：  
  • Hu
  • appl_detail：  
  • WB dilution:1:2000-10000
  • other_names：  
  • TDU; VGL1
  • Purification：  
  • Antigen affinity purification
  • Specificity：  
  • The antibody detects endogenous levels of total VGLL1 protein.
  • Applications：  
  • WB
  • Background：  
  • The protein encoded by this gene binds proteins of the TEA domain family of transcription factors (TEFs) through the Vg (vestigial) homology region found in its N-terminus. It may thus function as a specific coactivator for the mammalian TEFs. TDU interacted directly with the TEA domain family member, TEF1, and deletion of the Vg homology region abolished the interaction. The TDU-TEF1 dimer activated a reporter plasmid, and expression of TDU in Drosophila rescued loss of Vg function. The interaction was stronger in cardiac myocytes, suggesting a myocyte-specific factor may participate in the interaction. Vgll1 was weakly active in driving expression of a reporter gene from the mouse skeletal muscle alpha-actin promoter, and Vgll1 could partially reverse the inhibitory effect of TEF1 in this assay.



 
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