NGEF Antibody

Catalog Number:

47316

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q8N5V2
NCBI Gene ID:25791
Gene Accssion:BC031573

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human NGEF

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total NGEF protein.

Applications:

WB, IHC

Background:

Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).

References:

appl_detail:

WB dilution:1:500-2000
IHC dilution:1: 30-150

Datasheet PDF