Product Datasheet  
NGEF Antibody  
Catalog Number: 47316  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q8N5V2
    NCBI Gene ID:25791
    Gene Accssion:BC031573
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Fusion protein of human NGEF
  • reactivity：  
  • Hu, Ms, Rt
  • appl_detail：  
  • WB dilution:1:500-2000
    IHC dilution:1: 30-150
  • other_names：  
  • EPHEXIN; ARHGEF27
  • Purification：  
  • Antigen affinity purification
  • Specificity：  
  • The antibody detects endogenous levels of total NGEF protein.
  • Applications：  
  • WB, IHC
  • Background：  
  • Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).



 
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