RNF111 Antibody

Catalog Number:

47275

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q6ZNA4
NCBI Gene ID:54778
Gene Accssion:BC010369

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human RNF111

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total RNF111 protein.

Applications:

WB, IHC

Background:

The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.?

References:

appl_detail:

WB dilution:1:200-1000
IHC dilution:1: 50-300

Datasheet PDF