Product Datasheet  
RNF111 Antibody  
Catalog Number: 47275  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q6ZNA4
    NCBI Gene ID:54778
    Gene Accssion:BC010369
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Fusion protein of human RNF111
  • reactivity：  
  • Hu, Ms
  • appl_detail：  
  • WB dilution:1:200-1000
    IHC dilution:1: 50-300
  • other_names：  
  • ARK; hRNF111
  • Purification：  
  • Antigen affinity purification
  • Specificity：  
  • The antibody detects endogenous levels of total RNF111 protein.
  • Applications：  
  • WB, IHC
  • Background：  
  • The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.?



 
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